Solution of functional whitening raw materials

As consumers' requirements for the efficacy of skin care products continue to increase, the whitening track is ushering in a new round of upgrades. How to achieve truly visible skin brightening while ensuring safety and gentleness has become the core topic of brand research and development.

Sunzhou Sunland Pharmatech Co., Ltd. focuses on the research and development and production of effective active raw materials. With more than 10 years of experience in R&D of effective raw materials, its active products provide global skin care brands with high-purity, ultra-stable innovative whitening and skin rejuvenation ingredients, empowering the brand to create differentiated and high-performance skin care products.

The human pursuit of skin whitening spans cultures and eras, a desire woven into ideals of beauty, often reflecting deeper narratives of identity and aspiration.

Mechanism of Whitening

Method to control Internal factors

The picture showes that inhibiting melanin synthesis in melanocytes (e.g., blocking tyrosinase activity), accelerating the metabolism and excretion of formed melanin, or reducing UV-induced stimulation of melanin production, thereby lightening skin tone and improving pigmentation.

How TRAXMIC^TM Does its Work？

Tranexamic acid is of high-efficiency whitening can remove melanin and effectively reduce color spot.

             The red“ × ”marks the intervention sites of Tranexamic acid.

We can see that inhibiting the pathway between keratinocytes and melanocytes UV light, inflammation, and injury can cause changes in keratinocytes, which then produce PA (plasminogen activator).

The red cross in the diagram indicates that tranexamic acid may inhibit PA, blocking the transmission of certain signals from keratinocytes to melanocytes that promote melanin production, thereby inhibiting the differentiation, growth, and migration of melanocytes and reducing melanin production.

Fourfold whitening mechanism

    ✓Rapidly inhibits the activity oftyrosinase and melanocytes while blocking melanin aggregation.

    ✓Effectively slow the accumulation ofinflammation-induced melanin in the deep skin.

    ✓Effectively prevent the secondaryoxidation of melanin.

    ✓Effectively reduce the precipitated melanin and promote the separation of the produced melanin.

Vitamin C

Different between VC and VC derivatives

    ✓Stability & Formulation

Pure VC: Unstable—oxidizes fast in light/air/heat; needs dark, airtight packaging + stabilizers.

VC Derivatives: Highly stable; resists degradation; fits serums, creams, etc., no strict storage limits.

    ✓Penetration & Irritation

Pure VC: Poor penetration (hydrophilic); low pH causes stinging—bad for sensitive/barrier-damaged skin.

VC Derivatives Lipid-soluble，penetrate deeper; neutral pH minimizes irritation—safe for sensitive/acne-prone skin.

    ✓Efficacy  & Activation

Pure VC: Acts directly—blocks melanin, fades dark spots, fights free radicals (immediate effects).

VC Derivatives: Need conversion to active VC (delayed but sustained effects); some add extra benefits

Vitamin C Derivatives Additional Benefit

    ✓Inhibiting Melanin Production

They block tyrosinase activity, a key enzyme in melanin synthesis, reducing dark spots and uneven pigmentation.

    ✓Offering Antioxidant Protection

Neutralize free radicals that trigger skin discoloration, preventing UV-induced pigment darkening.

    ✓Boosting Collagen

Promote collagen synthesis, enhancing skin clarity by improving texture and reducing dullness.

    ✓Melanin Reduction

Help break down existing melanin deposits, brightening overall skin tone over time.

ActiBiso^TM  VCE

Inhibition of UV - induced DHICA Darkening

Different vitamin C derivatives (vitamin C, vitamin C glucoside, magnesium ascorbyl phosphate, and VCE, with different concentrations specified) show differences in their effects on inhibiting UV - induced darkening.

Among them, ActiBiso^TM VCE (at a 0. 1% concentration) has a relatively high inhibition rate (80%). The inhibition rate of vitamin C (at a 0. 1% concentration) is 70%. Both vitamin C glucoside and magnesium ascorbyl phosphate (at 0. 1%

concentrations) have an inhibition rate of 20%, and the inhibition rate of ActiBiso^TM VCE (at a 0.01% concentration) is 40%.

OtherVitamin C Derivatives

• Stability: Highest among all VC derivatives
• Irritation: Low (suitable for sensitive skin and pregnant women)
• All-round whitening (inhibition + reduction + antioxidation), compatible with all skin types, easy to compound with other ingredients

• Stability: Extremely high (fully liposoluble, completely resistant to light and oxygen)
• Irritation: Low (liposoluble structure reduces skin irritation)
• Good penetration with deep action, suitable for dry/combination skin; requires pairing with oil-based matrices to take effect

• Stability: High (water-soluble, light-resistant, ideal for aqueous formulations)
• Irritation: Extremely low (anti-inflammatory, suitable for sensitive & acne-prone skin)
• Mildest water-soluble VC derivative, combining whitening & soothing effects

Skin Whitening

• Stability: Medium (light protection needed; sensitive to pH & temperature)
• Irritation: Low (suitable for sensitive skin)
• Mild whitening effect (long-term use required for visible results)

• Stability: High (light & heat resistant, compatible with diverse formulations)
• Irritation: Extremely low (suitable for sensitive skin & post-medical aesthetic care)
• Signal-blocking whitening (no direct enzyme inhibition, mild & non-burdensome)

• Stability: High (stable chemical structure, hard to degrade)
• Irritation: Low to medium (possible redness in some cases; tolerance building needed)
• Stronger whitening efficacy than Alpha-Arbutin , suitable for skin with basic tolerance

• Stability: High (more stable than 4-Butylresorcinol)
• Irritation: Low (milder via improved molecular structure)
• Whitening & antioxidation; ideal for skin seeking "whitening + antioxidation" dual effects

Classification by mechanism of action

    ✓Enzyme inhibitors: Alpha-Arbut in, 4-Butylresorcinol,Hexylresorcinol (directly inhibit key enzymes in melanin synthesis)

    ✓Signal blockers: Undecylenoyl Phenylalanine (blocksproduction instructions without directly acting on enzymes)

    ✓VC derivatives: Ascorbyl Glucoside, AscorbylTetraisopalmitate, Sodium Ascorbyl Phosphate (need to convert to VC to take effect, and  have antioxidation effect)

    ✓Anti-inflammatory and mark-lightening type:Tranexamic Acid (targets post-inflammatoryhyperpigmentation with a unique mechanism).

Classification by stability&Irritation

   ✓Stability：High-Medium

。Ascorbyl Tetraisopalmitate

。Tranexamic Acid

。4-Butylresorcinol

。Alpha-Arbut in (needs to be stored away from light)

   ✓Irritation：Mild-Tolerance

。Undecylenoyl Phenylalanine, Sodium Ascorbyl Phosphate

。4-Butylresorcinol

With 10+ years of expertise in cosmetic actives R&D, Sunzhou Sunland Pharmatech Co., Ltd. deliver high-purity, ultra-stable ingredients tailored for brightening, anti-aging, acne-clearing, and moisturizing etc—empowering formulations that redefine skin health.In the future, we will continue to bring more breakthrough solutions to partners, helping the brand create the next generation of high-performance whitening products to meet consumers' pursuit of healthy and transparent skin tones.