Deep Whitening and Anti-Aging Combined-A Comprehensive Analysis of 3-O-Ethyl Ascorbic Acid

Bisor code: ActiBisoTM VCE
INCI Name: 3-0-Ethyl Ascorbic Acid
Other name: Ethyl ascorbic acid / 3-0-Ethyl Ascorbyl Ether
Molecular formula :C8H1206
CAS NO.: 86404-04-8
Molecular weight : 204.18

Vitamin Ethyl C is the derivative of Vitamin C, which is stable because it is metabolized as pure vitamin C in the living body, whereas conventional vitamin Chas a weakness that it is expedited to be oxidized ina normal subacid.
In the structure of Vitamin C, Vitamin C Ethylreplaces Ethoxy group in the 3rd place which hasstrong acid. Vitamin C Ethyl is protected from themetal ion. As a result it doesn't change in its colorand has nor abnormal reaction.
Recognized as a Whitening Ingredient by KFDAin 2001

This product not only delivers deep whitening and promotes collagen synthesis but also offers exceptional penetration and comprehensive antiaging benefits. 

FUNCTIONALITY--Whitening

Whitening agents made by Shiseido

➢ First generation: Tranexamic acid (TraxmicrM)
By in hibiting melanin cell activity to achieve whitening purposes, Shiseido's laboratory has demonstrated significantwhitening effects.

➢ Second generation: Arbutin (ActiBisoTM Arbutin )
Arbutin was originally discovered from bilberry, which can inhibit the activity oftyrosinase, thereby achieving the purpose ofinhibiting the production ofmelanin.

➢ Third Generation:Ascorbyl Glucoside (ActiBisoTM VCG)
Derivatives of VC are unstable in aqueous solution, and require whitening effect through the action ofenzymes in the skin

➢ Fourth Generation: 3-0-ethyl ascorbic acid (ActiBiso™M VCE)
The latest derivative of Vc, which is stable in water / alcohol solution, directly and quickly plays a role in whitening withoutthe need for enzyme conversion.

As shown in the image, after exposure to the sunfor 3 hours, the humanepidermal tissue was taken. It showed significantly deeperskin color.

From the image, it's clear that significant reduction inMelanin numbers afterapplication of ActiBisorTMVCE.

The photo showed that improvement effect of pigmented skin used 0.5%, 1%, 2% of ActiBiso^TM VCE for 3months

Stability test
Vitamin C is an excellent whitening and antioxidant raw material, but it is difficult to apply it to skin care products due to its stability (light, heat, air oxidation). ActiBisoTM VCE solves the problem of VC instability without changing the metabolism and efficacy of VC in the human body.
In the structure of Vitamin C, Vitamin C Ethyl replaces Ethoxy group in the 3rd place which has strong acid.
Vitamin C Ethyl is protected from the metal ion. As a result it doesn't change in its color and has nor abnormalreaction.

Toxicity Test

As illustrated by the picture ,this is an experiment of culturing human fibroblasts to test the effect of different concentrations of whitening agent on cell proliferation
It was found that VC is toxic to cells, ActiBisoTM VCE can promote cell proliferation, and other whitening agents have no significant effect on cell survival.

Purity test

➢ Equivalent content of vitamin C: indicates the proportion of each compound that can be converted into pure vitamin C. The prototype dimension C is the highest (99%), while Actibisovce is slightly lower (86.3%), but it belongs to a higher level.

➢ Molecular weight difference: the molecular weight of derivatives is generally greater than that of pure vitamin C, which affects their stability and permeability. Taking VCE as an example, the molecular weight is 204.18, which not only ensures stability, but also gives consideration to penetration.

➢ Solubility: all derivatives have good water solubility, and VCE can remain soluble in various solvents, which is convenient for formula application.

➢ Purity: actibisovce reaches the ultra-high purity of ≥99.5%, ensuring more stable efficacy; Other derivatives are also above 95%, which meets the requirements of cosmetic raw materials.

Generally speaking, this table clearly shows the advantages and disadvantages of various vitamin C active substances in the four core indexes of "vitamin C equivalent, molecular weight, solubility and purity", which provides intuitive basis for formulators to choose suitable derivatives.

Summrize
ActiBiso^TM VCE (3-O-ethyl ascorbic acid ) has been certified as a whitening ingredient by KFDA in Korea since 2001. It is stable in water/alcohol solution for a long time, light-resistant and heat-resistant (the buffer system at 40℃ is stable for 90 days), non-toxic to fibroblasts and can promote proliferation, and its vitamin C equivalent content is 86.3% and its ultra-high purity is ≥99.5%, which perfectly balances deep whitening and collagen.

Bisor Corporation is committed to the research and development and production of cosmetic active raw materials, focusing on core areas such as UV filter, whitening and anti-aging, aiming at bringing innovative, efficient and safe professional skin care solutions to the skin.

It has always been adhering to the concept of innovation and technology-driven, and is committed to providing efficient and reliable skin care solutions to consumers around the world. We firmly believe that through continuous research and innovation, we can bring more breakthrough skin care products to consumers and help them achieve healthier and more beautiful skin.