ActiBiso™ Calmin: A Novel Solution for Sensitive Skin and Post-Procedure Dermal Recovery

The effective, safe and non-hormonal anti-inflammatory and soothing ingredients are becoming the key point of brand differentiation competition in the functional skin care market.Especially in the subdivision track such as sun protection, sensitive muscles and postoperative repair, how to provide active substances with comparable efficacy but avoiding hormone side effects has become the focus of research and development.

Based on Euromonitor data, the annual growth rate of the "soothing and calming" skin care products market in the Asia-Pacific region has reached double digits, and the demand for non-steroidal anti-inflammatory substitutes is becoming more and more urgent.

In this context, ActiBiso™ Calmin (INCI: hydroxyl propamidobenzoic acid, CAS: 697235-49-7) introduced by Suzhou Sunland Pharmaceutical Technology Co., Ltd., as a new generation of targeted anti-inflammatory active substance, is providing strong raw material support for functional skin care products.

Product overview

Dihydro-oat alkaloids are derived from the active ingredient of Oats (Avena Sativa). The main ingredient is dihydro-oat alkaloid D. Oat alkaloids that have strong anti-inflammatory and anti-itonic properties. They are a powerful non-steroidal anti-inflammatory and anti-itonic natural ingredient. The titer is comparable to hydrocortisone, but they do not have any side effects of the steroid hormone.

Product Features

1）Oat alkaloids have multifunctional anti-inflammatory activities, including inhibiting the degradation of keratinous nuclear factor NF-KB-a, which is directly related to inflammation, and preventing the phosphorylation of the p65 protein subunit on the nuclear factor NF-KB., thereby blocking the occurrence of cellular inflammation, and having strong oxidative properties, which is conducive to the elimination of melanin.

2）Oat alkaloid can inhibit the activity of NF-K B degrading enzyme induced by tumor necrosis factor TNF-a, reduce the release of inflammatory factors and IL-8 leading to atopic dermatitis, and reduce the occurrence of inflammatory immune response and the reaction of cutaneous neurodermatitis. At the low concentration of 30ppm, oat alkaloids can greatly reduce the itching times of contact dermatitis and neurodermatitis.

Product testing:

First Test

✓ Test objective: To verify the effects of Dihydrooat alkaloids and antihistamine on skin itching and blister erythema.

✓ Test result: The application of histamine can cause severe itching, erythema and blisters on the skin. Dihydro-oat alkaloids can obviously alleviate skin abnormalities caused by histamine, such as itching, redness and blisters, and the relief effect on skin itching and erythema is dose-dependent. And can relieve skin pruritus and erythema caused by histamine at extremely low concentration.

Second Test

✓ Test objective: To verify the function of dihydrooat alkaloids in animals.

✓ Test method: The mice were fed without adding and dihydro-oat alkaloid feed at 0.1g/kg respectively, so as to see that this substance regulates the internal tissue oxidation and antioxidant balance of mice. In addition, after 50 days of feeding mice, the two groups of mice were divided into exercise groups and non-exercise groups to study the effect of dihydro-oat alkaloids on exercise-induced oxidative effects in the internal organ tissues of mice 

✓ Test result:

1）Supplementing dihydro oat alkaloids has no effect on the production of reactive oxygen species in most tissues except for reducing the reactive oxygen species in the soleus muscles of the mouse, which shows that dihydro oat alkaloids will not affect cell energy metabolism. Supplementing dihydrogen oat alkaloids can improve the activity of superoxide dismutase in the thigh muscles, liver and kidneys, and can improve the activity of glutathione peroxidase in the thigh muscles and heart.

2）Exercise can increase muscle and myocardial oxidative stress to increase reactive oxygen species and accelerate heart, liver and muscle peroxidation. Through experiments, dihydro oat alkaloids can relieve the production of reactive oxygen species caused by muscle exercise and can reduce fat peroxidation in the heart.

This suggests that dihydro-oat alkaloids can be added to the diet as effective antioxidants

Product Advantages

Cosmetics field

➤  Sun repair products: repair gel, spray, frozen film, soothing milk.

➤  Sensitive muscle care: barrier repair milk, soothing essence and microecological cream.

➤  Anti-allergic calming mask and water emulsion essence: first-aid mask, soothing spray, calming freeze-dried powder

➤  Anti-acne soothing products: anti-acne repair essence, acne patch and soothing emulsion.

➤  Babycare: baby buttock cream, children's soothing cream, fragrance-free care.

➤ Soothing products after shaving: aftershave water, soothing lotion and aftershave repair gel.

➤  Functional sunscreen products: used as synergistic activity enhancer in functional moisturizing, sunscreen and anti-allergic formulas.

Medicine field

➤  Post-repair of medical arts: gel, repair essence and dressing

➤  Post-sun/irritant dermatitis repair: soothing spray, calming gel

➤  Sensitive care for children/pregnant women: non-hormonal cream and anti-allergic essence

➤  Over-the-counter skin symptom relievers: anti-inflammatory ointment, antipruritic cream and skin barrier cream.

➤  Medical device skin dressings (EU CE system): liquid dressings, chronic care films and burn dressings.

Summarize

ActiBiso™ Calmin provides a reliable non-hormonal anti-inflammatory solution for functional skin care products and dermatological topical preparations with clear targeting mechanisms, drug-like titers and good use safety. It not only fills the gap in active substances between "efficiency + mildness", but also provides innovative support for the new generation of soothing, repairing and anti-allergic products.

With the increasing emphasis on "cosmeceutical" and "mild and effective" ingredients in the global market, ActiBiso™ Calmin is expected to be widely used in medical skin care, OTC skin treatment products, medical beauty restoration, baby care and other sub-tracks. 

In the future, Suzhou Sunland will continue to develop highly effective active substances around key mechanisms such as inflammation regulation, whitening and anti-aging, and promote ingredient innovation with science and technology, injecting new kinetic energy into global functional skin care and skin health management.