ActiBiso™ AMEA（Azelamide MEA） —— A new generation of sebum homeostasis regulating active components

In the innovative wave of functional skin care, sebum balance and skin barrier repair have become the focus of research and development. Consumers' dual demand for refreshing skin feeling and mild efficacy promotes the evolution of active raw materials to a more efficient, safer and more stable direction.Based on this, Suzhou Sunland Pharmatech Co., Ltd. successfully developed an innovative active ingredient ActiBiso™ AMEA (Azelamide MEA), a new generation of skin care raw material with multiple effects of lipid regulation, repair and anti-inflammation, relying on its technical accumulation in the fields of dermatology and molecular design.

I.Structuralinnovation: amidation modification empowers azelaic acid to upgrade again.

Traditional Azelic Acid has attracted much attention because of its excellent oil control and keratin conditioning, but its low solubility and potential irritation limit its wide application in high-end skin care formulations.

ActiBiso™ AMEA achieved a precise balance of molecular polarity by optimizing the amidation structure of azelaic acid and monoethanolamine (MEA):

●  Obviouslyimprove the water solubility and system stability

●  Effectively reduce skin irritation

●  Preserve and enhance the physiological activities of azelaic acid in lipid regulation and anti-inflammation.

This structural improvement makes ActiBiso™ AMEA have excellent dispersibility and skin sensation in the formula, which brings more possibilities for oily, acne and mixed skin products.

II.Scientificmechanism: two-way balance between lipid regulation and 

 ✓  Regulation of sebum secretion

ActiBiso™ AMEA can gently regulate the activity of sebaceous glands, reduce excessive secretion of oil, and improve the environment of pore obstruction and acne from the root.

 ✓  Barrier function strengthening

Studies have shown that this component can promote ceramide production in stratum corneum, improve sebum membrane structure, strengthen barrier function and significantly reduce percutaneous water loss (TEWL).

 ✓  Anti-inflammatory, soothing and antioxidant protection

ActiBiso™ AMEA can inhibit the release of inflammatory factors (such as IL-1β, TNF-α), and has the ability to scavenge free radicals, helping skin to resist environmental stress and oxidative stress.

III.Formulation advantages and application prospects

ActiBiso™ AMEA has excellent formula compatibility, can exist stably in the pH range of 4.5–7.0, and is suitable for:

✧   Oil balance and anti-acne series

✧   Sensitive muscle repair and soothing products

✧   Men's oil control care and scalp care products

✧   Refreshing texture essence, emulsion and mask formula

Its mild and safe characteristics make it an ideal core active substance of refreshing oil control+soothing repair formula.

IV.Green synthesisand quality assurance

Suzhou Sunland Pharmatech adheres to the R&D concept of safety, high efficiency and sustainability, and ActiBiso™ AMEA is synthesized by green chemical process to avoid organic solvent residue and heavy metal pollution. The product has high purity and good stability, and meets the requirements of ISO 16128 natural source standard and international cosmetics regulations.

ActiBiso™ AMEA -- Scientifically define the beauty of skin balance and provide efficient, safe and sustainable raw material solutions for global cosmetics brands.